“We don’t necessarily know if there is actually less symptomatology in the very young population,” she said.
Likewise, the reasons behind the study’s conclusion that during the first wave of MIS-C, from March 1 to July 1, 2020, young people were more prone to some of the more serious heart complications. Dr DeBiasi said this did not match his hospital experience, where “the children were sicker in the second wave”.
The study documented two waves of MIS-C cases that followed an increase of about a month or more in the total number of coronavirus cases. “The third most recent peak in the Covid-19 pandemic appears to lead to another MIS-C peak possibly involving urban and rural communities,” the authors wrote.
The study found that most of the states with the highest rate of MIS-C cases per population were in the northeast, which saw the first wave of cases, and in the south. In contrast, most states with high rates per population of children with Covid-19 but low rates of MIS-C were in the Midwest and West. Although the concentration of cases spread from large cities to small towns over time, it was not as pronounced as the overall trends in the pandemic, the authors said.
Dr Blumenthal said the geographic model might reflect that “understanding the complications of the disease” has not caught up with its prevalence in different regions or that many states with lower rates of MIS-C have less diverse populations on the planet. ethnically. “It could also be something about Covid itself, although we don’t know it,” she said. “At this time, we don’t know anything about how the variants necessarily affect children.”
The study only represented the most stringent criteria for MIS-C, excluding around 350 reported cases who met the CDC definition of syndrome but had a negative antibody test or mainly involved respiratory symptoms. Dr DeBiasi said there are also many probable cases of MIS-C that are not reported to the CDC because they do not meet all official criteria.
“These probable MIS-C kids, in real life that’s a big chunk of kids,” she said. Additionally, while the focus so far has been on severe cases, “there is another group of children who may actually have mild MIS-C.”
If a community has experienced a recent coronavirus outbreak, then “just because the child says, ‘I have never had Covid or my parents have never had it’, it does not mean that the child in front of you don’t have the MIS-C, ”Dr. DeBiasi said. “If your city has Covid, then prepare yourself.”